any1 ever seen nerd as huge as this... didnt think so haha :grin:
Vykromond.. You gotta dig deeper to find truly inaccessible/obscure literature. For instance, take your average science paper (this was literally the first result in a search for "stereochemistry" in the ACS Journal):
Originally posted by Vykromond
Prostaglandin H2 synthase has two isoforms, COX-1 and COX-2. COX-1 is constitutively expressed in mammalian tissues and supports prostaglandin synthesis necessary to maintain organ and tissue homeostasis.(14) In contrast, COX-2 is expressed in response to inflammatory stimuli.(15) Nonsteroidal anti-inflammatory drugs are relatively nonspecific, and since they target COX-1 as well as their intended COX-2 target, they can have adverse side effects such as gastrointestinal ulceration.(16, 17) Several strategies have been followed to reduce these adverse effects, including enteric coating, parenteral administration, formulation of pro-drugs that require hepatic metabolism for the cyclooxygenase (COX) activity to be unmasked, and coadministration of either suppressors of acid secretion or exogenous prostaglandins (PGs), without the desired results.(18) A structure-based drug design program has been instituted to create inhibitors that could specifically target COX-2 without affecting COX-1. Since the three-dimensional structures of COX-1 and COX-2 are almost identical, only a few drugs with selective activity have been successfully developed.(19, 20)
about what? that War asked me to join Sake cus they need my skill? and you claiming i almost joined? wtf war is a long time teammate since stray, ofcourse i wont tell him to fuck off, but i like to consider my self loyal to a squad for at least half a year if nothing bad is going on...e-fights and constant losing might turn me off from that promise but hey, theres nothing wrong with quake, so its very unlikely il leave to join someone else :/
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